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BCMB Friday Seminar: Gerald Hart Diedre Ribbens
Taverna Lab Spotlight Diedre Ribbens
Recent Job Postings Diedre Ribbens
Publication Spotlight Matt Shirley
Associate Director, in vivo Pharmacology – Seattle Genetics
Seattle Genetics is seeking a highly motivated and creative scientist to head the in vivo pharmacology group. The successful candidate will play an essential role in expanding our product pipeline, technology advancement, and understanding the mechanisms and immunological functions of our drugs. He/she will be a key player to maintain Seattle Genetics’ leadership in the field of antibody drug conjugates (ADC).
On Friday, February 15th, The BCMB Friday Seminar series hosted another faculty member of BCMB. This month, Gerald Hart of the Department of Biological Chemistry gave a talk entitled, “Linking nutrients to signaling and transcription: Roles of O-GlcNAcylation in diabetes, neurodegeneration, and cancer.”
Hart was introduced by a student in the Biological Chemistry department, Teresa Romeo-Luperchio. Luperchio gave a great run-down of Hart’s history as a scientist, including the fact that he used to have a lab in his bedroom when he was a child, complete with a Bunsen burner! Hart also founded the journal “Glycobiology.”
Hart began his talk by thanking BCMB program director Carolyn Machamer for organizing the seminar series, and for the opportunity to find out what his colleagues were doing.
Hart stated that the discovery of O-linked N-acetylglucosamine, better known as O-GlcNAc, occurred almost thirty years ago. Scientists thought that glycans were added in the lumen of the ER and Golgi, and were mostly on protein domains destined for outside of the cell. However, with the discovery of O-GlcNAc, they realized that glycosylation was occurring in the cytoplasm and nucleus as well. There have been approximately 1700 publications about O-GlcNAc and related processes since the 1980s.
Publication spotlight is a series designed to showcase noteworthy BCMB publications from students and faculty. If you have a recent publication that you are proud of, tell us about it.
Shilagardi K, Li S, Luo F, Marikar F, Duan R, Jin P, Kim JH, Murnen K, Chen
EH. Actin-Propelled Invasive Membrane Protrusions Promote Fusogenic Protein Engagement During Cell-Cell Fusion. Science. 2013 Mar 7. PubMed PMID: 23470732.
Chan W, Schaffer TB, Pomerantz JL. A quantitative signaling screen identifies CARD11 mutations in the CARD and LATCH domains that induce Bcl10 ubiquitination and human lymphoma cell survival. Mol Cell Biol. 2013 Jan;33(2):429-43. PMID: 23149938.
Tamura Y, Onguka O, Itoh K, Endo T, Iijima M, Claypool SM, Sesaki H. Phosphatidylethanolamine biosynthesis in mitochondria: phosphatidylserine (PS) trafficking is independent of a PS decarboxylase and intermembrane space proteins UPS1P and UPS2P. J Biol Chem. 2012 Dec 21;287(52):43961-71. PMID: 23124206.
Hobbs RP, Lessard JC, Coulombe PA. Keratin intermediate filament proteins – novel regulators of inflammation and immunity in skin. J Cell Sci. 2012 Nov 15;125(Pt 22):5257-8. PMID: 23377656.
If you have a publication you would like featured in this month’s Spotlight, please let us know.
PI Name: Sean Taverna
Number of Years in BCMB: 5
Model System(s): Yeast (S. cerevisiae), rats, C. elegans, mouse, Tetrahymena
Research Area: Understanding how the epigenome is regulated at a molecular level with a particular focus on histones and histone modifications.