Andrew Holland talks ASCB

Andrew Holland talks ASCB

BCMB faculty member Andrew Holland is a member of the American Society for Cell Biology. Here’s why he thinks you should be a member, too!

Professional societies like ASCB are a valuable resource for graduate students, postdocs, and faculty.

“The science of life, the life of science.” That’s the motto of The American Society for Cell Biology (ASCB), a professional organization founded in 1960 and headquartered in Bethesda, MD. There are many options for those who want to join a professional society, and ASCB membership is a great investment if your research is related to cell biology. Besides famously hosting one of the largest annual meetings in the United States, ASCB has many programs in place for science advocacy, education, and professional development. Many BCMB faculty are members of ASCB, including MBG professor Andrew Holland. “I believe in the work they’re doing,” says Holland, speaking admirably of ASCB’s policy and professional development efforts. “For ASCB it is all about their members and they will do anything they can to build a strong and successful community of cell biologists. In these times of diminishing funding it is more important than ever to have a strong voice advocating for basic research. ASCB is that voice and they work tirelessly on our behalf. I believe we all need to show our support.”

BCMB faculty member Andrew Holland

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Telling Stories about Science: My experiences as a science writer

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Could you be a freelance science writer? Read on to find out.

Many BCMB students have taken the elective course, taught by Jeremy Nathans, called Great Experiments in Biology. Year after year, students enjoy the class and recommend it to their peers. Why do we like it so well? Other than an appreciation and understanding for the great scientists who came before us, I think that we enjoy the class because Dr. Nathans focuses on the personal stories of the scientists: how they got interested in science, why they studied what they studied, how they reacted and felt and progressed along their path to these fantastic discoveries. In my experience, I always remember the science better when I understand the motivation behind the discovery; I loved discussing science with visiting lecturers and BCMB faculty not just for the academic part of the conversation, but also finding out the background and circuitous path they followed to get where they are today.

If you are finding yourself nodding and agreeing and connecting with what I just described, you might be interested in a career in science writing and communication. Here, I’ve “interviewed” myself; I hope this can stimulate some questions and discussion about our roles as scientists in the world of media and communication.

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BCMB Rocks!

Wow  — we all know our BCMB graduates are outstanding scientists, but check this out:

In the current issue of Science, two BCMB grads are first authors of RESEARCH ARTICLES!  Clara Bien Peek worked with Peter Espenshade and is currently a postdoc with Joseph Bass at Northwestern.  Jason McLellan worked with Dan Leahy, and recently started as an Assistant Professor at Dartmouth after a postdoc at the NIH with Peter Kwong.

Here are the links to these papers:

http://www.sciencemag.org/content/342/6158/1243417.full

http://www.sciencemag.org/content/342/6158/592.full

Congrats Clara and Jason!
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Publication Spotlight: May 2013

Publication spotlight is a series designed to showcase noteworthy BCMB publications from students and faculty. Articles we showcase are newly indexed in PubMed. If you have a recent publication that you are proud of tell us about it.

May

Baile MG, Whited K, Claypool SM. Deacylation on the Matrix Side of the Mitochondrial Inner Membrane Regulates Cardiolipin Remodeling. Mol Biol Cell. 2013 May 1. PMID: 23637464.

Zhang F, Bhat S, Gabelli SB, Chen X, Miller MS, Nacev BA, Cheng YL, Meyers DJ, Tenney K, Shim JS, Crews P, Amzel LM, Ma D, Liu JO. Pyridinylquinazolines Selectively Inhibit Human Methionine Aminopeptidase-1 in Cells. J Med Chem. 2013 May 1. PMID: 23634668.

April

Stine RR, Matunis EL. Stem cell competition: finding balance in the niche. Trends Cell Biol. 2013 Apr 15. PMID: 23597843.

Newman RH, Hu J, Rho HS, Xie Z, Woodard C, Neiswinger J, Cooper C, Shirley M, Clark HM, Hu S, Hwang W, Seop Jeong J, Wu G, Lin J, Gao X, Ni Q, Goel R, Xia S, Ji H, Dalby KN, Birnbaum MJ, Cole PA, Knapp S, Ryazanov AG, Zack DJ, Blackshaw S, Pawson T, Gingras AC, Desiderio S, Pandey A, Turk BE, Zhang J, Zhu H, Qian J. Construction of human activity-based phosphorylation networks. Mol Syst Biol. 2013 Apr 2. PMID: 23549483.

March

Huang Q, Purzycka KJ, Lusvarghi S, Li D, Legrice SF, Boeke JD. Retrotransposon Ty1 RNA contains a 5′-terminal long-range pseudoknot required for efficient reverse transcription. RNA. 2013 Mar. PMID: 23329695.

Shilagardi K, Li S, Luo F, Marikar F, Duan R, Jin P, Kim JH, Murnen K, Chen EH. Actin-Propelled Invasive Membrane Protrusions Promote Fusogenic Protein Engagement During Cell-Cell Fusion. Science. 2013 Mar 7. PMID: 23470732.

February

Han L, Ma C, Liu Q, Weng HJ, Cui Y, Tang Z, Kim Y, Nie H, Qu L, Patel KN, Li Z, McNeil B, He S, Guan Y, Xiao B, Lamotte RH, Dong X. A subpopulation of nociceptors specifically linked to itch. Nat Neurosci. 2013 Feb 16. PMID: 23263443.

If you have a publication you would like featured in this month’s Spotlight, please let us know.

Publication Spotlight: April 2013

Publication spotlight is a series designed to showcase noteworthy BCMB publications from students and faculty. Articles we showcase are newly indexed in PubMed. If you have a recent publication that you are proud of, tell us about it.

April

Newman RH, Hu J, Rho HS, Xie Z, Woodard C, Neiswinger J, Cooper C, Shirley M,
Clark HM, Hu S, Hwang W, Seop Jeong J, Wu G, Lin J, Gao X, Ni Q, Goel R, Xia S,
Ji H, Dalby KN, Birnbaum MJ, Cole PA, Knapp S, Ryazanov AG, Zack DJ, Blackshaw S,
Pawson T, Gingras AC, Desiderio S, Pandey A, Turk BE, Zhang J, Zhu H, Qian J.
Construction of human activity-based phosphorylation networks. Mol Syst Biol.
2013 Apr 2. PubMed PMID: 23549483.

March

Shilagardi K, Li S, Luo F, Marikar F, Duan R, Jin P, Kim JH, Murnen K, Chen
EH. Actin-Propelled Invasive Membrane Protrusions Promote Fusogenic Protein Engagement During Cell-Cell Fusion. Science. 2013 Mar 7. PubMed PMID: 23470732.

February

Han L, Ma C, Liu Q, Weng HJ, Cui Y, Tang Z, Kim Y, Nie H, Qu L, Patel KN, Li
Z, McNeil B, He S, Guan Y, Xiao B, Lamotte RH, Dong X. A subpopulation of
nociceptors specifically linked to itch. Nat Neurosci. 2013 Feb 16. PubMed PMID: 23263443.

January

Chan W, Schaffer TB, Pomerantz JL. A quantitative signaling screen identifies CARD11 mutations in the CARD and LATCH domains that induce Bcl10 ubiquitination and human lymphoma cell survival. Mol Cell Biol. 2013 Jan;33(2):429-43. PMID: 23149938.

October (2012)

West-Foyle H, Robinson DN. Cytokinesis mechanics and mechanosensing.
Cytoskeleton (Hoboken). 2012 Oct.  PubMed PMID: 22761196.

If you have a publication you would like featured in this month’s Spotlight, please let us know.

Gerald Hart BCMB Friday Seminar

On Friday, February 15th, The BCMB Friday Seminar series hosted another faculty member of BCMB.  This month, Gerald Hart of the Department of Biological Chemistry gave a talk entitled, “Linking nutrients to signaling and transcription:  Roles of O-GlcNAcylation in diabetes, neurodegeneration, and cancer.”

Hart was introduced by a student in the Biological Chemistry department, Teresa Romeo-Luperchio.  Luperchio gave a great run-down of Hart’s history as a scientist, including the fact that he used to have a lab in his bedroom when he was a child, complete with a Bunsen burner!  Hart also founded the journal “Glycobiology.”

BCMB Student Teresa Romeo-Luperchio, from the Department of Biological Chemistry, introduces Gerald Hart.

BCMB Student Teresa Romeo-Luperchio, from the Department of Biological Chemistry, introduces Gerald Hart.

Hart began his talk by thanking BCMB program director Carolyn Machamer for organizing the seminar series, and for the opportunity to find out what his colleagues were doing.

Hart stated that the discovery of O-linked N-acetylglucosamine, better known as O-GlcNAc, occurred almost thirty years ago.  Scientists thought that glycans were added in the lumen of the ER and Golgi, and were mostly on protein domains destined for outside of the cell.  However, with the discovery of O-GlcNAc, they realized that glycosylation was occurring in the cytoplasm and nucleus as well.  There have been approximately 1700 publications about O-GlcNAc and related processes since the 1980s.

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Publication Spotlight: March 2013

Publication spotlight is a series designed to showcase noteworthy BCMB publications from students and faculty. If you have a recent publication that you are proud of, tell us about it.

March

Shilagardi K, Li S, Luo F, Marikar F, Duan R, Jin P, Kim JH, Murnen K, Chen
EH. Actin-Propelled Invasive Membrane Protrusions Promote Fusogenic Protein Engagement During Cell-Cell Fusion. Science. 2013 Mar 7. PubMed PMID: 23470732.

January

Chan W, Schaffer TB, Pomerantz JL. A quantitative signaling screen identifies CARD11 mutations in the CARD and LATCH domains that induce Bcl10 ubiquitination and human lymphoma cell survival. Mol Cell Biol. 2013 Jan;33(2):429-43. PMID: 23149938.

November

Tamura Y, Onguka O, Itoh K, Endo T, Iijima M, Claypool SM, Sesaki H. Phosphatidylethanolamine biosynthesis in mitochondria: phosphatidylserine (PS) trafficking is independent of a PS decarboxylase and intermembrane space proteins UPS1P and UPS2P. J Biol Chem. 2012 Dec 21;287(52):43961-71. PMID: 23124206.

Hobbs RP, Lessard JC, Coulombe PA. Keratin intermediate filament proteins – novel regulators of inflammation and immunity in skin. J Cell Sci. 2012 Nov 15;125(Pt 22):5257-8. PMID: 23377656.

If you have a publication you would like featured in this month’s Spotlight, please let us know.